Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes
نویسندگان
چکیده
منابع مشابه
Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes.
New genes can arise by duplication and divergence, but there is a fundamental gap in our understanding of the relationship between these genes, the evolving proteins they encode, and the fitness of the organism. Here we used crystallography, NMR dynamics, kinetics, and mass spectrometry to explain the molecular innovations that arose during a previous real-time evolution experiment. In that exp...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1618552114